Biosynergics Job Positions

Sr. Principal Scientist or Director, Antibody Drug Discovery

Company Description

Biosynergics Incorporation (BSI) is a Nanjing-based start-up biotech company focusing on the discovery and development of the innovative biologics for the unmet medical needs. With our proprietary H3 (High-throughput High-content High-efficiency) antibody platform and SynAbTM technology, BSI is committed to the development of biological molecules with superior drug properties and/or with novel mechanism of actions to known and novel drug targets.

Location: Greater Philadelphia, USA and/or Nanjing, China

Job Description and Responsibilities

  1. Develop and execute strategies for target identification, prioritization and validation; review, propose, initiate, and implement new pre-clinical therapeutic antibody drug discovery and development programs.
  2. Represent in-house expertise in antibody drug discovery, engineering, and development, as well as one or more disease areas of immunology, oncology, and cardiovascular biology.
  3. Collaborate with CRO and academic partners, employ cutting-edge in vitro and in vivo animal and human cancer models to advance drug discovery and development programs up to and including IND filing.
  4. Facilitate the writing of patents and regulatory documents. Present non-proprietary results on scientific conferences and publish in peer-reviewed journals.

Qualification requirements

  1. PhD in immunology or cancer biology, plus 5 ~ 10 year experience in antibody drug discovery
  2. Experience of leading a drug discovery project in biopharmaceutical company
  3. Expertise of in vitro ell-based functional assays, and complex co-culture biology assays
  4. Extensive experience in multi-color flow cytometry.
  5. Knowledge in skills of cell biology and/or in vivo models is also highly desirable.

Sr. Principal Scientist or Director, Antibody Engineering

Company Description

Biosynergics Incorporation (BSI) is a Nanjing-based start-up biotech company focusing on the discovery and development of the innovative biologics for the unmet medical needs. With our proprietary H3 (High-throughput High-content High-efficiency) antibody platform and SynAbTM technology, BSI is committed to the development of biological molecules with superior drug properties and/or with novel mechanism of actions to known and novel drug targets.

Location: Greater Philadelphia, USA and/or Nanjing, China

Job Responsibilities

  1. Lead the design, generation, humanization and affinity maturation of antibody derived from our H3 antibody platform
  2. Implement humanization and affinity maturation strategies.
  3. Designing, cloning and transfection of expression constructs;
  4. Expression, purification and characterization of binders;
  5. Determination of kinetic constants;
  6. Epitope binning and mapping;

Qualification requirements

  1. Ph.D. in molecular biology or cell biology with 5 years of industry experience
  2. Experience in engineering and expression of monoclonal antibodies, Fabs, scFvs, sdAbs and proteins
  3. Expertise in humanization, affinity maturation, and reformatting of antibodies
  4. Extensive experience with characterization of antibodies and proteins using a variety of biophysical and biochemical techniques (PAGE & Western blots, ELISA, SEC, DSC, Fortebio, epitope mapping, etc.)
  5. Proven track record of scientific accomplishments demonstrated by publications in high-impact journals

 

Sr. Principal Scientist or Director, Cell Line Development

Company Description

Biosynergics Incorporation (BSI) is a Nanjing-based start-up biotech company focusing on the discovery and development of the innovative biologics for the unmet medical needs. With our proprietary H3 (High-throughput High-content High-efficiency) antibody platform and SynAbTM technology, BSI is committed to the development of biological molecules with superior drug properties and/or with novel mechanism of actions to known and novel drug targets.

Location: Greater Philadelphia, USA and/or Nanjing, China

Job Responsibilities

  1. Responsible for establishing mammalian cell line development platform and generating high producing cell lines for the production of recombinant proteins, including fusion protein and monoclonal antibody.
  2. Performing key activities associated with production cell line development including transfection, selection, single cell cloning, high throughput screening, characterization of clonal cell lines using scale-down models, cell banking, and cell line stability studies.
  3. Developing and optimizing new protein expression platform including designing, constructing, and evaluating novel expression constructs and expression system.
  4. Managing development projects with external partners and outsourcing activities.
  5. Writing technical reports and presenting data in project and group meetings.
  6. Supervising direct reports as functional team grows.

Qualification requirements

  1. PhD in Biological Sciences, Molecular Biology, Biochemical Engineering with over 6-8 years of industrial cell line development experience
  2. Extensive experience with generating high-producing mammalian production cell line.
  3. Experience with DNA cloning, vector design and construction, and genetic characterization of production cell banks is required.
  4. Experience with high throughput immunological assays such as Octet assay, ELISA, and FACS analysis.
  5. Extensive and hands on experience with FACS Sorting.
  6. In depth knowledge of antibody technology, protein expression, and regulatory guideline for recombinant protein expression.

Manager/director of Bio Drug Discovery

Position: Manager of Bio-Drug Discovery

Department: R&D

Reporting line: VP/CSO

Career Path: Director/Senior Director

Working Location: Nanjing

Working Environment: Office and management orientated

Responsibilities:

  • Lead drug discovery projects–plan, assign work, review data and manage resources
  • Coordinate different functional lines – internal R&D teamsQC, external CRO service providers and collaborators
  • Monitor progress, control quality and ensure delivery on time and on budge
  • Write/review project documentations- research plans, protocols and progress reports and final reports
  • Work on multiple projects
  • Communicate with key clients, organize joint meetings
  • Other tasks assigned by higher management

Qualifications:

  • PhD degree in cell biology, immunology or biotechnology or other related field
  • At least 2-3 years working experiences
  • Candidates with industry experience is preferred
  • Excellent organizational skills and be very detail oriented
  • An excellent communicator in verbal and writing forms and a good listener
  • Good documentation and computer skills (PP, Word, Excel, etc.) are required
  • Strong in spoken and written English
  • A positive attitude to any feedback both internally and externally

 

 

Contact person: Larry Li, VP
Email: [email protected]
China mobile : (86) 135-6439-0335
USA mobile: (01) 508-410-6008
Website: http://www.biosynergics.com.cn/index_en.php
Address: Building 30 699-18 Xuanwu Avenue Nanjing, Jiangsu 210042, China Phone: (86) 025-8650-7191 | Tax: (86) 025-8650-7191 | Email: [email protected]
2017-07-04T17:56:37+00:00